cirrhosis 2 3 Running title : Escherichia coli and cirrhosis 4 5
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چکیده
24 25 Among patients with cirrhosis, infections caused by Escherichia coli organisms that 26 translocate from the gut are a frequent and severe complication. One hundred-ten E. coli 27 isolates from 110 cirrhotic patients with spontaneous bacterial peritonitis and/or spontaneous 28 bacteremia were characterized for phylogenetic group and virulence genotype (34 29 extraintestinal virulence factor genes). Genetic relatedness was investigated by ERIC-2 PCR 30 typing and multi-locus sequence typing. Phylogenetic groups A, B1, B2, and D accounted for 31 24%, 4%, 48%, and 24% of the population, respectively. Overall, 68 distinct ERIC-2 profiles 32 were encountered. Eleven clonal groups, represented by multiple isolates (2 to 11) from the 33 same sequence type or sequence type complex, were identified. These clonal groups 34 accounted for 54 (49%) isolates overall. Membership in one of these clonal groups was more 35 frequent among B2 isolates than non-B2 isolates (67% vs. 32%, p < 0.001). The most frequent 36 sequence types were ST95 (n = 13) and ST73 (n = 8), followed by the ST14 and ST10 37 complexes (n = 7). ST131 and ST69 were represented by 3 isolates each. Clonal group38 associated isolates exhibited a greater prevalence of 11 virulence genes, including pap 39 elements, than did other isolates. However, no association between clonal groups and host 40 factors, type of infection, or mortality was observed. In conclusion, E. coli isolates causing 41 spontaneous bacterial peritonitis and bacteremia in cirrhotic patients are genetically diverse. 42 However, approximately half of the isolates belong to familiar clonal groups and exhibit 43 extensive virulence profiles that may be associated with greater invasive potential. 44 on O cber 2, 2017 by gest ht://jcm .sm .rg/ D ow nladed fom
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تاریخ انتشار 2010